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 OverView
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My main research focuses on the identification of molecular, epigentic and metabolic markers for early diagnosis of diseases, treatment responses and resistance in different diseases including breast cancer, hyperlipidemia and drug?s toxicity in cell lines and animal models using gene expression analysis, flow cytometry, DNA methylation, and capillary electrophoresis followed by the correlation with patients survival towards future personalized treatment.
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 Research Intersets:
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Cancer research, Hyperlipidemia, treatment resistance, disease biomarkers
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 Qualifications
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Degree
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University
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Specialization
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Graduation year
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| 1 | PHD | Putra Malaysia University | Biochemistry | 2008 | | 2 | MASTER DEGREE | Putra Malaysia University | Medical Microbiology | 2003 | | 3 | BACHELOR'S DEGREE | University of Jordan | Pharmacy | 1999 |
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 Experiences
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Academic Experience:
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 2008 -2023 :Professor,Al-Zaytoonah University of Jordan,Jordan.
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Administrative Experience:
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 Publications
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1- Cytotoxic and molecular differences of anticancer agents on 2D and 3D cell culture ,Molecular Biology Reports , 2024,Vol. 51,no. 1.
2- The Role of Vitamin E in Protecting against Oxidative Stress,
Inflammation, and the Neurotoxic Effects of Acute Paracetamol
in Pregnant Female Rats ,Toxics, 2023,Vol. 11,no. 368.
3- Sumc (Rhus coriaria L.) fruit ameliorates paracetamol-induced hepatotoxicity ,Food Bioscience, 2023,Vol. 52,no. .
4- Bortezomib advanced mechanisms of action in multiple myeloma, solid and liquid tumors along with its novel therapeutic applications ,EXCLI Journal, 2023,Vol. 22,no. .
5- Extraction of Anthocyanins from Black Grape By-Products and
Improving Their Stability Using Cobalt(II) Complexation ,Preventive Nutrition and Food Science, 2022,Vol. 27,no. 4.
6- Shedding Light on Pharmacists' Knowledge of Kidney Stones' Etiology and Treatment ,Pharmacy Practice, 2022,Vol. 20,no. 3.
7- Investigation of the Effect of Imatinib and Hydroxyurea
Combination Therapy on Hematological Parameters and Gene
Expression in Chronic Myeloid Leukemia (CML) Patients ,Journal of Clinical Medicine, 2022,Vol. 11,no. .
8- Automated online monitoring of lactate and pyruvate in tamoxifen resistant MCF-7 cells using sequential-injection capillary electrophoresis with contactless conductivity detection (SI-CE-C4D) and correlation with MCT1 and MCT4 genes expression ,Journal of Liquid Chromatography and Related Technologies, 2022,Vol. 45,no. 1?4 .
9- Assessment of persistent
antimicrobial and anti?biofilm
activity of p?HEMA hydrogel
loaded with rifampicin and cefxime ,Scientific Reports, 2022,Vol. 12,no. .
10- Lactate and pyruvate levels correlation with lactate dehydrogenase gene expression and glucose consumption in Tamoxifen-resistant MCF-7 cells using capillary electrophoresis with contactless conductivity detection (CE-C4D) ,Electrophoresis, 2021,Vol. 43,no. 3.
11- Determination of Antimicrobial and Antibiofilm Activity of Combined LVX and AMP Impregnated in p(HEMA) Hydrogel ,Applied Sciences, 2021,Vol. 11,no. 18.
12- High Performance Liquid Chromatography?Tandem Mass
Spectrometry Method for Correlating the Metabolic Changes of
Lactate, Pyruvate and L-Glutamine with Induced Tamoxifen
Resistant MCF-7 Cell Line Potential Molecular Changes ,Molecules, 2021,Vol. 26,no. 16.
13- PI3K/AKT and MAPK1 molecular changes preceding matrix metallopeptidases overexpression during tamoxifen-resistance development are correlated to poor prognosis in breast cancer patients ,Breast Cancer, 2021,Vol. 28,no. .
14- Cytotoxicity and Cellular Death Modality of Surface-Decorated Gold Nanorods against a Panel of Breast Cancer Cell Lines ,ACS Omega, 2021,Vol. 6,no. 24.
15- Changes in Lactate Production, Lactate Dehydrogenase Genes Expression and DNA Methylation in Response to Tamoxifen Resistance Development in MCF-7 Cell Line ,Genes, 2021,Vol. 12,no. 5.
16- Doxorubicin?paclitaxel sequential treatment: insights of DNA methylation and gene expression changes of luminal A and triple negative breast cancer cell lines ,Molecular and Cellular Biochemistry, 2021,Vol. 476,no. .
17- Upregulation of PI3K/AKT/PTEN pathway is correlated with glucose and glutamine metabolic dysfunction during tamoxifen resistance development in MCF-7 cells ,Scientific Reports, 2020,Vol. 10,no. .
18- Nanoparticle size and chemical modification play a crucial role in the interaction of nano gold with the brain: extent of accumulation and toxicity ,Biomaterials Science, 2020,Vol. 8,no. .
19- Insights into the Cellular Uptake, Cytotoxicity, and Cellular Death Modality of Phospholipid-Coated Gold Nanorods toward Breast Cancer Cell Lines ,Molecular Pharmaceutics, 2019,Vol. 16,no. 10.
20- Gold nanoparticles loaded into polymeric hydrogel for wound healing in rats: Effect of nanoparticles? shape and surface modification ,International Journal of Pharmaceutics, 2019,Vol. 565 ,no. .
21- Hypolipidemic effect of novel 2,5-bis(4-hydroxybenzylidenamino)-1,3,4-thiadiazole as potential peroxisome proliferation-activated receptor-? agonist in acute hyperlipidemic rat model , Molecular and Cellular Biochemistry, 2019,Vol. 458,no. .
22- Second exposure to acetaminophen overdose is associated with liver fibrosis in mice ,EXCLI Journal, 2019,Vol. 18,no. .
23- Culturing conditions highly affect DNA methylation and gene expression levels in MCF7 breast cancer cell line ,In Vitro Cellular & Developmental Biology - Animal, 2018,Vol. 54,no. .
24- Synthesis of Novel Benzimidazole-2-carboxamide Derivatives and in Vivo
Antihyperlipidemic Activity Evaluation ,Chemical and Pharmaceutical Bulletin, 2018,Vol. 66,no. .
25- N-(3-Benzoylphenyl)-1H-Indole-2-Carboxamide decreases triglyceride levels by downregulation of Apoc3 gene expression in acute hyperlipidemic rat model ,Molecular and Cellular Biochemistry, 2017,Vol. 431,no. .
26- Highlight report: pluripotent stem cells in translational research ,Archives of Toxicology, 2016,Vol. 90,no. .
27- Calreticulin mediates an invasive breast
cancer phenotype through the transcriptional
dysregulation of p53 and MAPK pathways ,Cancer Cell International, 2016,Vol. 16,no. .
28- Novel Pyrrole Derivatives as Potent lipid-Lowering Agents
in Triton-WR-1339-Induced Hyperlipidemic Rats ,Latin American Journal of Pharmacy, 2015,Vol. 34 ,no. 6.
29- The Pharmacological effects of novel 5-fluoroN-(9,10-dihydro-9,10-dioxoanthracen-8-yl)-1Hindole-2-carboxamide derivatives on plasma lipid
profile of Triton-WR-1339-induced Wistar rats ,Journal of Enzyme Inhibition and Medicinal Chemistry, 2013,Vol. 28,no. 4.
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